(Bloomberg) — At least five people were killed Tuesday night, and dozens of others injured, when an Amtrak train headed to New York City derailed in Philadelphia, shutting down part of the busiest passenger rail corridor in the U.S.

Northeast Regional Train 188, which originated in Washington, went off the tracks about 9:30 p.m., sending more than 50 people to hospitals for treatment, according to the city’s fire department. The cause wasn’t immediately known.

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