(Bloomberg) -- At least five people were killed Tuesday night, and dozens of others injured, when an Amtrak train headed to New York City derailed in Philadelphia, shutting down part of the busiest passenger rail corridor in the U.S.

Northeast Regional Train 188, which originated in Washington, went off the tracks about 9:30 p.m., sending more than 50 people to hospitals for treatment, according to the city’s fire department. The cause wasn’t immediately known.

An engine and seven cars careened off the tracks, according to Kevin Thompson, a spokesman for the Federal Railroad Administration. Three cars were resting on their sides and one almost on its roof. One car was perpendicular to the others.

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